Reduced Inhibition and Sensitivity to Neurosteroids in Hippocampus of Mice Lacking the GABAA Receptor Subunit
نویسندگان
چکیده
Igor Spigelman, Zhiwei Li, Jing Liang, Elisabetta Cagetti, Sepideh Samzadeh, Robert M. Mihalek, Gregg E. Homanics, and Richard W. Olsen Division of Oral Biology and Medicine, UCLA School of Dentistry, Los Angeles, California 90095; Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095; and Department of Anesthesiology/Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260
منابع مشابه
Allopregnanolone suppresses diabetes-induced neuropathic pain and motor deficit through inhibition of GABAA receptor down-regulation in the spinal cord of diabetic rats
Objective(s):Painful diabetic neuropathy is associated with hyperexcitability and hyperactivity of spinal cord neurons. However, its underlying pathophysiological mechanisms have not been fully clarified. Induction of excitatory/inhibitory neurotransmission imbalance at the spinal cord seems to account for the abnormal neuronal activity in diabetes. Protective properties of neurosteroids have b...
متن کاملPrenatal stress increased γ2 GABAA receptor subunit gene expression in hippocampus and potentiated pentylenetetrazol-induced seizure in rats
Objective(s): Stress during pregnancy is able to bring extensive effects on neurobehavioral development in offspring. The GABAergic system plays a pivotal role in neuronal excitability, which can be affected by prenatal stress (PS). This study aimed to evaluate impact of the PS on γ2 subunit of gamma-aminobutyric acid A (GABAA) receptor gene expression in the hippocamp...
متن کاملFinal Accepted Version Reduced Inhibition and Sensitivity to Neurosteroids in Hippocampus of Mice Lacking the Gabaa Receptor Δ Subunit
We thank Kate Baicy for expert technical assistance. Abstract The subunit of the-aminobutyric acid (A) receptor (GABA A R) is expressed postnatally mostly in the cerebellum, thalamus and dentate gyrus. Previous studies in mice with a targeted disruption of the subunit revealed a considerable attenuation of behavioral responses to neuroactive steroids, but not to other neuromodulatory drugs. Her...
متن کاملPerimenstrual-like hormonal regulation of extrasynaptic δ-containing GABAA receptors mediating tonic inhibition and neurosteroid sensitivity.
Neurosteroids are endogenous regulators of neuronal excitability and seizure susceptibility. Neurosteroids, such as allopregnanolone (AP; 3α-hydroxy-5α-pregnan-20-one), exhibit enhanced anticonvulsant activity in perimenstrual catamenial epilepsy, a neuroendocrine condition in which seizures are clustered around the menstrual period associated with neurosteroid withdrawal (NSW). However, the mo...
متن کاملGenetic Inactivation of the Serotonin1A Receptor in Mice Results in Downregulation of Major GABAA Receptor a Subunits, Reduction of GABAA Receptor Binding, and Benzodiazepine-Resistant Anxiety
Anxiety is a common psychiatric illness often treated by benzodiazepines (BZs). BZs, such as Valium, bind to the a subunit of the pentameric GABAA receptor and increase inhibition in the CNS. There is considerable evidence for abnormal GABAA receptor function in anxiety, and a significant proportion of anxiety patients has a reduced sensitivity to BZs. Here, we show that serotonin1A (5-HT1A) re...
متن کامل